[at-l] Re: Aspirin - probably OT

[orangebug74@yahoo.com (Orange Bug)]

Anklebear asked me to forward this to the list as my version of what
the Aspirin article was trying to get across. The pharmacokinetics of
aspirin is probably not all that on topic, so delete at will (as if you
would do otherwise). The metaphor I was working on involved a shapely
young lass, Barry White, Ozzie Osbourne, and Lawrence Welk. 

You don't want to go there.

Bill...

--- lbooher <lbooher@adelphia.net> wrote:
> From: "lbooher" <lbooher@adelphia.net>
> To: "Orange Bug" <orangebug74@yahoo.com>
> Subject: Re: [at-l] Re: Aspirin
> Date: Sat, 13 Apr 2002 00:10:25 -0400
> 
> Thanks a lot.  I understand your description.  You should post this
> to the list.  You have my permission.  <G>  BTW, I believe in
> aspirin, and I've never fooled with those other things.  anklebear
> 
> ----- Original Message -----
> From: Orange Bug <orangebug74@yahoo.com>
> To: lbooher <lbooher@adelphia.net>
> Sent: Friday, April 12, 2002 11:56 PM
> Subject: Re: [at-l] Re: Aspirin
> 
> 
> > This is the problem with medical literature. The wording is "dumbed
> > down" to a point, but the concept is a bit subtle.
> >
> > Aspirin is ancient. Motrin and more recently invented drugs are
> > "special" and referred to as NSAIDs, particularly before many went
> > over the counter without prescriptions.
> >
> > The article refers to a receptor site (keyhole) on a platelet's
> > outer coating. Certain body chemicals that indicate injury or
> > inflammation hit that keyhole and tell platelets to be sticky and
> > clump together - aggregate. This starts a cascade of events
> > leading to a clot of blood. 
> >
> > If that clot stops a vessel from bleeding outside - this is good.
> > If that clot stops a vessel from delivering oxygen to something
> > important - like a part of your brain - this is not good.
> >
> > Aspirin finds a way to stick to that little receptor site and keep
> > most body chemicals from telling the platelet how to do their job.
> > It gets in that spot, like epoxy in a keyhole.
> >
> > Motrin can get into that keyhole, but more like silly putty and can
> > get bumped out by those chemicals - but keeps Aspirin out totally.
> > When Motrin gets into that keyhole, it doesn't do as good a job of
> > keeping platelets from getting sticky.
> >
> > So, if you take Aspirin first thing in the AM, it finds the keyhole
> > and stops it up for the rest of the next few days. If you take and
> > Advil for a headache, no problem as the Aspirin has found a home
and
> > ain't moving.
> >
> > If first thing of a morning you took Advil/Motrin/Vit I, it sticks
> > on the receptor/keyhole just enough to keep Aspirin out but not
> > enough to keep chemicals out that make platelets go sticky. If
> > you take that Advil just once, no big deal because there are other
> > platelet stuck up with Aspirin in their keyholes enough to keep
> > clumping down.
> >
> > If you are taking Motrin every day because of your bad knees from
> > hiking 15 mile days, there ain't anyway Aspirin will find a way
> > into enough keyholes to do its job on the platelets.
> >
> > In the article, Voltaren (interesting that a lister was started on
> > that this week) and Tylenol did not have the same interaction as
> > Motrin.
> >
> > So that is a little description of what the article was trying to
> > get across. I'm sure the NEJM article was even more obtuse. I've
> > been thinking along the lines of a sexual metaphor as in A
Beautiful
> > Mind, but I think it would be even more confusing or insulting.
> >
> > Bill....
> >
> > --- lbooher <lbooher@adelphia.net> wrote:
> > > That article left me in the dust.  I tried correcting the grammar
> > > to see if that helped any, but it didn't.  I read through it
> > > lightly, but nothing made a lot of sense to me, except that they
> > > said that aspirin is counteracted by NSAIDs, of which I had
> > > thought aspirin was one.
> > > You agree with that, it looks like.  anklebear
> >

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